Blar i forfatter "Smith-Byrne, Karl"

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    • Body Size at Different Ages and Risk of 6 Cancers: A Mendelian Randomization and Prospective Cohort Study 

      Mariosa, Daniela; Smith-Byrne, Karl; Richardson, Tom G.; Ferrari, Pietro; Gunter, Marc J.; Papadimitriou, Nikos; Murphy, Neil; Christakoudi, Sofia; Tsilidis, Konstantinos K.; Riboli, Elio; Muller, David; Purdue, Mark P.; Chanock, Stephen J.; Hung, Rayjean J.; Amos, Christopher I.; O'Mara, Tracy A.; Amiano, Pilar; Pasanisi, Fabrizio; Rodriguez-Barranco, Miguel; Krogh, Vittorio; Tjønneland, Anne; Halkjær, Jytte; Perez-Cornago, Aurora; Chirlaque, María-Dolores; Skeie, Guri; Rylander, Charlotta; Borch, Kristin Benjaminsen; Aune, Dagfinn; Heath, Alicia K.; Ward, Heather A.; Schulze, Matthias; Bonet, Catalina; Weiderpass, Elisabete; Davey Smith, George; Brennan, Paul; Johansson, Mattias (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-19)
      It is unclear if body weight in early life affects cancer risk independently of adult body weight. To investigate this question for 6 obesity-related cancers, we performed univariable and multivariable analyses using 1) Mendelian randomization (MR) analysis and 2) longitudinal analyses in prospective cohorts. Both the MR and longitudinal analyses indicated that larger early life body size was ...

    • Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts 

      Rothwell, Joseph A.; Bešević, Jelena; Dimou, Niki; Breeur, Marie; Murphy, Neil; Jenab, Mazda; Wedekind, Roland; Viallon, Vivian; Ferrari, Pietro; Achaintre, David; Gicquiau, Audrey; Rinaldi, Sabina; Scalbert, Augustin; Huybrechts, Inge; Prehn, Cornelia; Adamski, Jerzy; Cross, Amanda J.; Keun, Hector; Chadeau-Hyam, Marc; Boutron-Ruault, Marie-Christine; Overvad, Kim; Dahm, Christina C.; Nøst, Therese Haugdahl; Sandanger, Torkjel M; Skeie, Guri; Zamora-Ros, Raul; Tsilidis, Kostas K.; Eichelmann, Fabian; Schulze, Matthias B.; van Guelpen, Bethany; Vidman, Linda; Sánchez, Maria-José; Amiano, Pilar; Ardanaz, Eva; Smith-Byrne, Karl; Travis, Ruth; Katzke, Verena; Kaaks, Rudolf; Derksen, Jeroen W. G.; Colorado-Yohar, Sandra; Tumino, Rosario; Bueno-de-Mesquita, Bas; Vineis, Paolo; Palli, Domenico; Pasanisi, Fabrizio; Eriksen, Anne Kirstine; Tjønneland, Anne; Severi, Gianluca; Gunter, Marc J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-28)
      Background Amino acid metabolism is dysregulated in colorectal cancer patients; however, it is not clear whether pre-diagnostic levels of amino acids are associated with subsequent risk of colorectal cancer. We investigated circulat‑ ing levels of amino acids in relation to colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) and UK Biobank ...

    • Circulating free testosterone and risk of aggressive prostate cancer: Prospective and Mendelian randomisation analyses in international consortia 

      Watts, Eleanor L.; Perez-Cornago, Aurora; Fensom, Georgina K.; Smith-Byrne, Karl; Noor, Urwah; Andrews, Colm D.; Gunter, Marc J.; Holmes, Michael V.; Martin, Richard M.; Tsilidis, Konstantinos K.; Albanes, Demetrius; Barricarte, Aurelio; Bueno-de-Mesquita, Bas; Chen, Chu; Cohn, Barbara A.; Dimou, Niki L.; Ferrucci, Luigi; Flicker, Leon; Freedman, Neal D.; Giles, Graham G.; Giovannucci, Edward L.; Goodman, Gary E.; Haiman, Christopher A.; Hankey, Graeme J.; Huang, Jiaqi; Huang, Wen-Yi; Hurwitz, Lauren M.; Kaaks, Rudolf; Knekt, Paul; Kubo, Tatsuhiko; Langseth, Hilde; Laughlin, Gail; Le Marchand, Loic; Luostarinen, Tapio; MacInnis, Robert J.; Mäenpää, Hanna O.; Männistö, Satu; Metter, E. Jeffrey; Mikami, Kazuya; Mucci, Lorelei A.; Olsen, Anja; Ozasa, Kotaro; Palli, Domenico; Penney, Kathryn L.; Platz, Elizabeth A.; Rissanen, Harri; Sawada, Norie; Schenk, Jeannette M.; Stattin, Pär; Tamakoshi, Akiko; Thysell, Elin; Tsai, Chiaojung Jillian; Tsugane, Shoichiro; Vatten, Lars Johan; Weiderpass, Elisabete; Weinstein, Stephanie J.; Wilkens, Lynne R.; Yeap, Bu B.; Allen, Naomi E.; Key, Timothy J.; Travis, Ruth C. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-17)
      Previous studies had limited power to assess the associations of testosterone with aggressive disease as a primary endpoint. Further, the association of genetically predicted testosterone with aggressive disease is not known. We investigated the associations of calculated free and measured total testosterone and sex hormone-binding globulin (SHBG) with aggressive, overall and early-onset prostate ...

    • Circulating Isovalerylcarnitine and Lung Cancer Risk: Evidence from Mendelian Randomization and Prediagnostic Blood Measurements 

      Smith-Byrne, Karl; Cerani, Agustin; Guida, Florence; Zhou, Sirui; Agudo, Antonio; Aleksandrova, Krasimira; Barricarte, Aurelio; Barranco, Miguel Rodríguez; Bochers, Christoph H.; Gram, Inger Torhild; Han, Jun; Amos, Christopher I.; Hung, Rayjean J.; Grankvist, Kjell; Nøst, Therese Haugdahl; Imaz, Liher; Chirlaque-López, María Dolores; Johansson, Mikael; Kaaks, Rudolf; Kühn, Tilman; Martin, Richard M.; McKay, James D.; Pala, Valeria; Robbins, Hilary A.; Sandanger, Torkjel M; Schibli, David; Schulze, Matthias B.; Travis, Ruth C.; Vineis, Paolo; Weiderpass, Elisabete; Brennan, Paul; Johansson, Mattias; Richards, J Brent (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-04)
      Background: Tobacco exposure causes 8 of 10 lung cancers, and identifying additional risk factors is challenging due to confounding introduced by smoking in traditional observational studies.<p> <p>Materials and Methods: We used Mendelian randomization (MR) to screen 207 metabolites for their role in lung cancer predisposition using independent genome-wide association studies (GWAS) of blood ...

    • Lung cancer risk discrimination of prediagnostic proteomics measurements compared with existing prediction tools 

      Feng, Xiaoshuang; Wu, Wendy Yi-Ying; Onwuka, Justina Ucheojor; Haider, Zahra; Alcala, Karine; Smith-Byrne, Karl; Zahed, Hana; Guida, Florence; Wang, Renwei; Bassett, Julie K.; Stevens, Victoria; Wang, Ying; Weinstein, Stephanie; Freedman, Neal D.; Chen, Chu; Tinker, Lesley; Nøst, Therese Haugdahl; Koh, Woon-Puay; Muller, David; Colorado-Yohar, Sandra M.; Tumino, Rosario; Hung, Rayjean J.; Amos, Christopher I.; Lin, Xihong; Zhang, Xuehong; Arslan, Alan A.; Sánchez, Maria-Jose; Sørgjerd, Elin Pettersen; Severi, Gianluca; Hveem, Kristian; Brennan, Paul; Langhammer, Arnulf; Milne, Roger L.; Yuan, Jian-Min; Melin, Beatrice; Johansson, Mikael; Robbins, Hilary A.; Johansson, Mattias (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-01)
      Background: We sought to develop a proteomics-based risk model for lung cancer and evaluate its risk-discriminatory performance in comparison with a smoking-based risk model (PLCOm2012) and a commercially available autoantibody biomarker test.<p><p>Methods: We designed a case-control study nested in 6 prospective cohorts, including 624 lung cancer participants who donated blood samples at most 3 ...

    • Prediagnosis Leisure-Time Physical Activity and Lung Cancer Survival: A Pooled Analysis of 11 Cohorts 

      Yang, Jae Jeong; Yu, Danxia; White, Emily; Lee, Dong Hoon; Blot, William; Robien, Kim; Park, Yikyung; Takata, Yumie; Gao, Yu-Tang; Smith-Byrne, Karl; Monninkhof, Evelyn M; Kaaks, Rudolf; Langhammer, Arnulf; Borch, Kristin Benjaminsen; Al-Shaar, Laila; Lan, Qing; Sørgjerd, Elin Pettersen; Zhang, Xuehong; Zhu, Clair; Chirlaque, María Dolores; Severi, Gianluca; Overvad, Kim; Sacerdote, Carlotta; Aune, Dagfinn; Johansson, Mattias; Smith-Warner, Stephanie A; Zheng, Wei; Shu, Xiao-Ou (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-14)
      Background: Little is known about the association between physical activity before cancer diagnosis and survival among lung cancer patients. In this pooled analysis of 11 prospective cohorts, we investigated associations of prediagnosis leisuretime physical activity (LTPA) with all-cause and lung cancer–specific mortality among incident lung cancer patients. <p><p>Methods: Using self-reported data ...

    • Reproductive and hormonal factors and risk of renal cell carcinoma among women in the European Prospective Investigation into Cancer and Nutrition 

      Clasen, Joanna L.; Mabunda, Rita; Heath, Alicia K.; Kaaks, Rudolf; Katzke, Verena; Schulze, Matthias B.; Birukov, Anna; Tagliabue, Giovanna; Chiodini, Paolo; Tumino, Rosario; Milani, Lorenzo; Braaten, Tonje Bjørndal; Gram, Inger Torhild; Lukic, Marko; Luján-Barroso, Leila; Rodriguez-Barranco, Miguel; Chirlaque, María-Dolores; Ardanaz, Eva; Amiano, Pilar; Manjer, Jonas; Huss, Linnea; Ljungberg, Börje; Travis, Ruth; Smith-Byrne, Karl; Gunter, Marc; Johansson, Matthias; Rinaldi, Sabina; Weiderpass, Elisabete; Riboli, Elio; Cross, Amanda J.; Muller, David C. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-03)
      Background - Renal cell carcinoma (RCC) is twice as common among men compared with women, and hormonal factors have been suggested to partially explain this difference. There is currently little evidence on the roles of reproductive and hormonal risk factors in RCC aetiology.<p> <p>Materials & Methods - We investigated associations of age at menarche and age at menopause, pregnancy-related factors, ...